HPLC Method Validation for Determination of Pentoxifylline in Pharmaceutical Dosage Forms
Nasser Thallaj*, Assistant Professor, Department of Pharmaceutical Chemistry and Drug Quality Control, Faculty of Pharmacy, Al-Rachid University, Damascus, Syria.
Manuscript received on October 04, 2021. | Revised Manuscript received on February 02, 2022. | Manuscript published on April 30, 2022. | PP: 5-9 | Volume-1 Issue-3, April 2022 | Retrieval Number: 100.1/ijac.C2012041322 | DOI: 10.54105/ijac.C2012.041322
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Abstract: Selective and simple reversed phase High Performance Liquid Chromatography (RP-HPLC) method was developed and validated for quantification of pentoxifylline in dosage forms available in local market. Firstly, different chromatographic conditions were tested. Then, the optimized method was validated. The method proven to be linear over 50% to 150% of the nominal concentration of standard pentoxifylline (R2 0.994). The method was accurate (recovery 100.1%) and precise (RSD% <3%). The method could separate pentoxifylline of caffeine and degradation products. The method was suitable for routine analysis of pentoxifylline in tablet dosage forms.
Keywords: Stability Indicating-HPLC: Pentoxifylline: Caffeine: Validation, Pentoxifylline: Validation.
Scope of the Article: Pharmaceutical Chemistry