Synthesis, Characterization, and Evaluation of the Antibacterial Activity of Some Novel Thiazolo- [1,2,4] Triazolo [1,5-a] Pyridine Derivatives
Pendam Prashanth Babu1, Pingili Upendra2, Dharanipathi Venkateshwar Rao3
1Dr. Pendam Prashanth Babu, Professor, Department of Chemistry, Sree Chaitanya College of Engineering, Karimnagar, Hyderabad (Telangana), India.
2Dr. Pingili Upendra, Assistant Professor, Department of Chemistry, Government Degree College for Women (Autonomous), Nalgonda, Hyderabad (Telangana), India.
3Dr. Dharanipathi Venkateshwar Rao, Assistant Professor, Department of Chemistry, Government Degree College, Ibrahimpatnam, Ranga Reddy, Hyderabad (Telangana), India.
Manuscript received on 02 May 2025 | First Revised Manuscript received on 19 May 2025 | Second Revised Manuscript received on 16 September 2025 | Manuscript Accepted on 15 October 2025 | Manuscript published on 30 October 2025 | PP: 1-6 | Volume-5 Issue-2, October 2025 | Retrieval Number: 100.1/ijac.B203005021025 | DOI: 10.54105/ijac.B2030.05021025
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Abstract: A novel four-step scientific protocol has been reported for the synthesis of thiazolo- [1,2,4] triazolo[1,5-a] pyridine and its derivatives (6a-c) as target moieties in good overall yields by using 1-(2-(Trifluoromethyl)-5-methylthiazol-4- yl) ethanone (1) as starting compound. The IR, PMR, Mass spectral data, and elemental analysis validated the chemical structures of all the intermediates and products. Furthermore, the newly synthesised intermediates and final derivatives were screened for their antibacterial activity against different bacterial strains, and it was found that a few of them exhibited noteworthy antibacterial activity with varying degrees of disparity.
Keywords: Thiazole, 1,2,4-Triazole, Pyridine Derivatives, Antibacterial Activity.
Scope of the Article: Organic Chemistry